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Macrophage Pharma Expands Executive Team with Chief Scientific Officer and Chief Technology Officer

Key hires enhance management for next development phase

09 January 2020, Windsor, UK: Macrophage Pharma Limited (“MPL”), a biotech company focused on the discovery and development of next-generation immunomodulatory small molecules inducing transcriptional reprogramming of macrophage function to combat cancer and other diseases, announced today that it has appointed Venkat Reddy PhD as Chief Scientific Officer (CSO) and David Moffat PhD, MPL co-founder and former director of chemistry, as Chief Technology Officer (CTO).

Commenting on the appointments, Dr Søren Bregenholt, MPL Chief Executive Officer said: “On behalf of the executive team I am pleased to welcome Venkat as CSO and David in his new role as CTO as the Company progresses to its next stage of development. Venkat’s deep understanding of pharmaceutical R&D, extensive experience in drug discovery, translational research and early development combined with David’s profound knowledge of our foundation Esterase Sensitive MotifTM (ESMTM) technology, which he co-invented, and drug discovery, will continue to be invaluable as we advance towards clinical trials this year, diversify the technology platform and build out the pipeline to address multiple indications.”

Dr. Venkat Reddy, CSO of Macrophage Pharma, commented: “I am excited to join Macrophage Pharma as CSO and look forward to advancing and expanding the Company’s unique technology platform, exemplified by a drug candidate on track to enter clinical trials. This novel platform allows us to manipulate macrophage and other immune cell functions with the potential to impact areas of unmet need. The differentiation of MPL’s foundation technology from contemporary immune-oncology approaches offers an effective route to functional manipulation of macrophages in the tumour microenvironment by inhibiting local immunosuppression and leading to more effective anti-tumour immune responses. I look forward to working with the management and board to unlock the full therapeutic potential of the ESMTM platform to deliver first-in-class therapeutics to patients with significant pathologies.”

Dr. David Moffat, CTO, MPL, added: “I am very pleased to be taking the helm as CTO at MPL as we progress our lead asset into clinical trials and diversify and advance our preclinical pipeline to embrace additional drug targets and lead chemistries. The differentiated approach of our technology has the reach to address multiple indications where the immune system is dysregulated by aberrant macrophage activity, for potentially wide-ranging clinical benefit. As co-originator of the ESMTM technology I am proud of MPL’s achievements to date and look forward to working with our enhanced team in support of the further growth and development of Macrophage Pharma.”

Venkat brings over 15 years of experience in the biopharmaceutical industry most recently with Glenmark Pharmaceuticals where he was a senior vice president and global head of translational sciences leading the translational programmes of the Company’s innovative preclinical and clinical portfolio. He co-founded APC Therapeutics Inc., a small molecule immuno-oncology startup, the lead programme of which was licensed to Glenmark. Previously, Dr Reddy acted as a senior director of strategic partnerships at Pfizer’s Center for Therapeutic Innovation. Prior to that he held roles with Sanofi, as head of bio-innovation and as global head of oncology target discovery where he was involved in target identification and validation (TIDVAL) function and progression of multiple programmes from preclinical to clinical trials. Before joining Sanofi, Dr Reddy was a group leader in oncology drug discovery at the Novartis Institute for Functional Genomics, San Diego. He received his PhD in human biology at Ludwig Maximilians Universität, Munich and completed a post-doctoral fellowship in oncology and immunology at Scripps Research Institute, La Jolla.

Dr Moffat co-founded MPL in November 2014 and is co-inventor in the discovery and development of the ESMTM technology platform. Previously he has been director of chemistry at Chroma Therapeutics from 2004 to 2012, during which three molecules from his chemistry team were progressed to the clinic including the macrophage-targeted histone deacetylase inhibitors CHR-2845 and CHR-5154. He was also head of chemistry at Celltech from 2001 to 2004, prior to its acquisition by UCB, having begun his industrial career there in 1989. Dr Moffat has extensive experience in oncology and inflammation preclinical research and has led groups which have identified numerous clinical development candidates in these therapeutic areas. He holds BSc and PhD degrees from the University of Glasgow and is author and inventor on more than 70 patents and publications.

Macrophage Pharma at JP Morgan Healthcare Conference, San Francisco

Søren Bregenholt and Venkat Reddy will be at the 38th Annual J.P. Morgan Healthcare Conference on 13-16 January 2020 in San Francisco, California.

Søren Bregenholt will also be presenting at Biotech Showcase 2020 (13-15 January 2020) on Monday 13th January 2020 at 3pm in Franciscan B (Ballroom Level).

Please get in touch, details below, if you would like to set up a meeting.

ENDS

About Macrophage Pharma

Based on its proprietary Esterase Motif Technology™ (ESM™) platform, Macrophage Pharma is developing a novel and unique class of small molecule therapeutics which modulate immune responses though transcriptional reprogramming of monocytes and macrophages to combat disease. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The Company is developing multiple programs inhibiting key pathways in macrophages in disease including the lead, a macrophage targeted p38 MAPK inhibitor programme.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Funds, Novo Holdings A/S and M Ventures. Please visit the company website for further information: dev.macrophage.jacklogic.com

Contacts:

Macrophage Pharma Limited

Dr Søren Bregenholt, Chief Executive Officer,

Email: sb@macrophagepharma.com

Tel: +45 27284533

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur

Email: hollie@optimumcomms.com

Tel: +44 (0) 203 714 1789

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Macrophage Pharma Appoints Dr Anker Lundemose to the Board of Directors

Appointment widens industry leadership perspective, translational and commercial expertise

26 September 2019, Windsor, UK: Macrophage Pharma Limited (‘MPL’), a company focused on the discovery and development of next-generation immunomodulatory small molecules inducing transcriptional reprofiling of macrophages to combat cancer and other diseases, announced today that it has appointed Dr. Anker Lundemose as independent non-executive director.

Commenting on the appointment, Dr Michael Moore, Chairman of Macrophage Pharma, said: “On behalf of the Board I am pleased to welcome Anker as an independent director who has developed an outstanding reputation for having founded and built several successful companies within the European biotech sector.  As MPL evolves into the next stage of its development Anker will prove a valuable resource in the translation of the products of our proprietary Esterase Sensitive Motif™ (ESM™) platform and in the formulation of commercial strategies to bring our macrophage-directed small molecule drugs to cancer patients and those with other serious diseases.

Dr Anker Lundemose, said: “I am very happy to join Macrophage Pharma as an independent director, and I look forward to working closely with my new board colleagues and the CEO to take the Company to the next stage. The ESM™ platform with its pharmaceutical potential to achieve macrophage transcriptional reprogramming in several diseases, is impressive and differentiated from other immunomodulatory approaches.  With the current configuration of seasoned investors, CEO and executive team, the Company is well positioned to leverage that potential for the benefit of patients and all stakeholders.”

Anker Lundemose is a Danish national and currently Chief Executive Officer of Mission Therapeutics Ltd in Cambridge, UK. In a biopharma career spanning over twenty-five years, he brings extensive international experience in areas of management, business development, corporate development, R&D strategy & execution, and financing. Moreover, Anker has successfully built and exited several biotech companies and has cumulative experience in both public and private companies. Currently he is a director of Antag Therapeutics and Inthera Biosciences.  Anker has MD, PhD and DMSc degrees from the University of Aarhus, Denmark

ENDS         

About Macrophage Pharma

Based on its proprietary Esterase Motif Technology™ (ESM™) platform, Macrophage Pharma is developing a novel and unique class of small molecule therapeutics which modulate immune responses though transcriptional reprogramming of monocytes and macrophages to combat disease. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The company is developing multiple programs inhibiting key pathways in macrophages in disease including the lead, a macrophage targeted p38MAP inhibitor programme for cancer.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Funds, Novo Holdings A/S and M Ventures. Please visit the company website for further information: dev.macrophage.jacklogic.com

Contacts:

Macrophage Pharma Limited

Dr Soren Bregenholt, Chief Executive Officer,

Email: sb@macrophagepharma.com

Tel: +45 27284533

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur

Email: hollie@optimumcomms.com

Tel: +44 (0) 203 950 9144

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Macrophage Pharma Appoints Dr Søren Bregenholt as Chief Executive Officer

Strategic and operational leadership expanded for progressing broad pipeline 

03 September 2019, Windsor, UK: Macrophage Pharma Limited (‘MPL’), a company focused on the discovery and development of next-generation immunomodulatory small molecules inducing transcriptional reprofiling of macrophages to combat cancer and other diseases, announced today that it has appointed Dr Soren Bregenholt as Chief Executive Officer.

Commenting on the appointment, Dr Michael Moore, Chairman of Macrophage Pharma, said: “The Board is delighted to have attracted Søren to Macrophage Pharma. Soren’s outstanding track record from executive positions in both biotech and pharma, as well as his extensive expertise and insight in immunology, will be invaluable as we further develop and commercialise our proprietary Esterase Sensitive Motif™ (ESM™) platform and evolve Macrophage Pharma into a leading biotech company.”

Dr Søren Bregenholt, CEO of Macrophage Pharma, said: “I am excited to join Macrophage Pharma as CEO. The Company’s unique and proprietary ESM™ technology platform is a compelling strategy for inducing transcriptional reprofiling of monocytes and macrophages and represents a differentiated approach to modulation of a centrally important regulator of the immune response across a variety of human diseases. I look forward to working with management and Board to unlock the full therapeutic and commercial potential of the technology in both cancer and non-cancer fields.”

Søren Bregenholt PhD is a Danish national with an extensive operational and strategic track record from the biotech and pharmaceutical industries. He previously held senior executive roles including COO and CBO at Danish biotech companies Symphogen and IO Biotech, respectively. As part of the global R&D Management at Novo Nordisk, Søren was responsible for the global R&D Strategy and External Innovation efforts. Currently, Søren serves as Chairman of the Board at the Danish-Swedish life science organization Medicon Valley Alliance. His academic career, at the University of Copenhagen and Institute Pasteur, Paris, has focussed on immunoregulation and immunopathology in cancer and other diseases.

About Macrophage Pharma

Based on its proprietary Esterase Motif Technology™ (ESM™) platform, Macrophage Pharma is developing a novel and unique class of small molecule therapeutics which modulate immune responses though transcriptional reprogramming of monocytes and macrophages to combat disease. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The company is developing multiple programs inhibiting key pathways in macrophages in disease including the lead, a macrophage targeted p38MAPi programme for cancer.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Fund II, Novo Holdings A/S and M Ventures. Please visit the company website for further information: dev.macrophage.jacklogic.com

Contacts:

Macrophage Pharma Limited

Dr Soren Bregenholt, Chief Executive Officer,

Email: sb@macrophagepharma.com

Tel: +45 2728 4533

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur

Email: macrophage@optimumcomms.com

Tel: +44 (0) 203 9509144

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Macrophage Pharma Announces Appointment of Leading International Scientific Advisory Board

10th September 2018, Windsor, UK: Macrophage Pharma Limited (‘MPL’), a company focused on the discovery and development of next-generation small molecules aiming to modulate immune responses to combat cancer and other diseases, announced today the formation of an international Scientific Advisory Board (SAB).

The Scientific Advisory Board will closely work with management team as it seeks to maximise the potential of its proprietary Esterase Sensitive Motif™ (ESM™) platform and evolve Macrophage Pharma into a leading immunotherapy company.

The Scientific Advisory Board includes:

  • Tanja de Gruijl Ph.D., Professor, Translational Tumor Immunology and Head Immunotherapy Lab at Amsterdam University Medical Centers, Vrije Universiteit Cancer Center, Amsterdam
  • Liza Makowski Ph.D., Professor in the Department of Medicine, Division of Hematology and Oncology, University of Tennessee Health Science Center
  • Alberto Mantovani M.D., Professor, Humanitas University, Scientific Director, Istituto Clinico Humanitas IRCCS, Milan and Chair of Inflammation and Therapeutic Innovation, William Harvey Research Institute, Queen Mary University, London
  • Luke O’Neill Ph.D., Professor and Head of Department of Biochemistry, Trinity College Dublin
  • Mike Owen Ph.D., Chairman of the Board of Ossianix Inc and Director of Zealand Pharma, Avacta Group plc, ReNeuron plc and GammaDelta Therapeutics
  • Laszlo Radvanyi Ph.D., President & Scientific Director, Ontario Institute for Cancer Research (OICR), Toronto, Canada.

On welcoming the members to the SAB, Steven Powell, CEO of Macrophage Pharma, said: “We are delighted to have attracted this stellar group of experts to our Advisory Board.  Their collective knowledge and experience in the field of immunology and oncology will be invaluable as we seek to realise the full therapeutic potential of our ESM™ technology in both cancer and non-cancer fields.”

ENDS

For further information please contact:

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur

Email: macrophage@optimumcomms.com

Tel: +44 (0) 203 714 1789

About Macrophage Pharma

Macrophage Pharma is developing a highly novel class of small molecule therapeutics which modulate immune responses to combat disease based on its proprietary Esterase Motif Technology™ (ESM™) platform. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The lead p38MAPi programme is focused on a novel macrophage-targeting p38 MAPK inhibitor. Clinical trials are scheduled to start in 2019. The Company’s R&D pipeline includes additional programmes with proprietary compounds targeting a number of targets.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Fund II, Novo Holdings A/S and M Ventures. Please visit the company website for further information: dev.macrophage.jacklogic.com

 

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Macrophage Pharma Appoints Dr Michael Moore as Chairman

11 April 2018, Windsor, UK: Macrophage Pharma Limited (‘MPL’), a company focused on the discovery and development of next-generation small molecules aiming to modulate immune responses to combat cancer and other diseases, announced today that it has appointed Dr. Michael Moore as non-executive Chairman with immediate effect.

Commenting on the appointment, Steven Powell, CEO of Macrophage Pharma, said: “Michael’s outstanding track record in building both private and public biotech companies, as well as his expertise and insight into the field of immunology, will be invaluable as we develop and commercialise our proprietary Esterase Sensitive Motif™ (ESM™) platform and evolve into a leading immunology company.”

Dr Michael Moore, Chairman of Macrophage Pharma, said: “I am impressed by Macrophage Pharma’s unique and proprietary ESM™ technology platform and its differentiated approach to the modulation of immune function in disease. I look forward to working with the Executive team and my new Board colleagues as we seek to realise the full therapeutic potential of ESM™ technology in both cancer and non-cancer fields.”

Dr Michael Moore has extensive experience in drug discovery and development and is currently a non-executive director of several private and public bioscience companies, including Mission Therapeutics, of which he was Founder Chairman, NASDAQ-listed Trillium Therapeutics Inc. and Mironid Limited.  He is currently Chairman of Chronos Therapeutics and was Founder Chairman of PsiOxus Therapeutics.  Dr Moore was previously CEO of Piramed, acquired by Roche in 2008, and Research Director and CSO of Xenova Group plc. Prior to joining the UK biotechnology sector, he had an extensive academic research career, principally at the Paterson Institute for Cancer Research and the University of Manchester Medical School, where he was Honorary Reader in immunology and oncology.  Dr Moore holds PhD and DSc degrees from the University of Nottingham, fellowship of the Royal College of Pathologists and is a past Chairman of Cancer Research UK’s drug discovery committee.

ENDS       

For further information please contact:

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur

Email: hollie@optimumcomms.com

Tel: +44 (0) 203 714 1789

About Macrophage Pharma

Macrophage Pharma is developing a highly novel class of small molecule therapeutics which modulate immune responses to combat disease based on its proprietary Esterase Motif Technology™ (ESM™) platform. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The lead p38MAPi programme is focused on a novel macrophage-targeting p38 MAPK inhibitor. Clinical trials are scheduled to start in 2019. The Company’s R&D pipeline includes additional programmes with proprietary compounds targeting a number of targets.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Fund II, Novo Holdings A/S and M Ventures. Please visit the company website for further information: dev.macrophage.jacklogic.com