Macrophages are important effector cells in the human immune system and are found in almost every tissue in the human body. They are crucial to functioning of both the innate and adaptive elements of the immune system with different, but related, macrophage types both activating and suppressing the immune response as well as being involved in wound healing and secretion of regulatory cytokines.
Pharmaceutical manipulation of macrophage function offers a promising way to treat diseases in which the macrophage function or the immune system is either malfunctioning or imbalanced.
Key regulators of macrophage function, and thus targets for transcriptional reprogramming, such as kinases molecules and transcription factors, also play key role in other immune cells like T and B lymphocytes, NK cells, granulocytes, as well as epithelial and stromal cells.
Selective macrophage-targeting of small molecule inhibitors thus be used to affect selectively reprogram macrophages without interfering with the function of other cell types, leading to better efficacy and less unwanted pharmacology and less side effects.
Macrophages & Disease
Macrophages are important effector cells in the human immune system, found in almost every tissue in the human body.
The ESM Technology involves the use of specifically designed amino acid ester motifs that are selectively hydrolysed.