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Macrophage Pharma Appoints Dr Venkat Reddy as Chief Executive Officer

Executive leadership and strategic focus strengthened for sustained company development

01 June 2021, Windsor, UK: Macrophage Pharma Limited (‘MPL’), a company focused on the discovery and early stage development of highly novel small molecule therapeutics with the potential to transform outcome in inflammation, autoimmune disease and cancer through regulation of innate immune response, announced today that its Chief Scientific Officer (CSO), Dr Venkat Reddy PhD, has been appointed by the Board as Chief Executive Officer (CEO).

Commenting on the appointment, Dr Michael Moore, Chairman of Macrophage Pharma, said: “The Board is delighted to have promoted Venkat to CEO. Since joining the Company, Venkat’s influence in combining a strategic biology focus on targets critical for regulated cell death in immune-mediated diseases with the Company’s drug discovery platform based on proprietary Esterase Sensitive Motif™ (ESM™) technology, has been transformative, enhancing the opportunity for commercialisation of our novel small molecule assets for a variety of protein targets and therapeutically unmet diseases.”
Dr Venkat Reddy, CEO of Macrophage Pharma, commented: “I am honoured to have been appointed CEO of Macrophage Pharma. The potential of our ESM™ technology platform to generate novel drugs is compelling as demonstrated by its ability to impact adaptive immunity through selective modulation of myeloid derived innate immune cells. I look forward to continuing my work with Macrophage Pharma’s executive team and Board of Directors to unlock the full therapeutic and commercial potential of the technology across a spectrum of human diseases.”

Venkat Reddy has a successful track record and extensive strategic and management experience from senior executive roles in both European and US biotech and pharma, including Glenmark Pharmaceuticals (SVP, Global Head of Translational Sciences), Pfizer (Senior Director, Strategic Alliances and Partnerships, Centers for Therapeutic Innovation), Sanofi (Senior Director, Head, Bio-Innovation France: Global Biotherapeutics) and Novartis (Group leader, GNF). Venkat holds a PhD from the Ludwig-Maximilians Universität München and undertook post-doctoral studies in immunology and oncology at the Scripps Research Institute. He has served Macrophage Pharma as Chief Scientific Officer since January 2020.


Macrophage Pharma Limited
Dr Venkat Reddy, Chief Executive Officer

Optimum Strategic Communications
Hollie Vile, Mary Clark, Elakiya Rangarajah
Tel: +44 (0) 020 3922 0900

Upcoming Events

Whilst we are all learning to adapt and live with the restrictions imposed by COVID-19, the team at Macrophage Pharma look forward to seeing you in person at events in the near future. In the meantime, this is where to find us (virtually) in the spring…

About 14th Annual European Life Sciences CEO Forum (

BIO-Europe Spring | Europe’s Largest Springtime Biotech Partnering Digital Event (

European Biotech Investor Days 2021 « Solebury Trout Access

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17th Annual Anglonordic Life Science Conference

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Our News

Macrophage Pharma Expands Executive Team with Chief Scientific Officer and Chief Technology Officer

Key hires enhance management for next development phase

09 January 2020, Windsor, UK: Macrophage Pharma Limited (“MPL”), a biotech company focused on the discovery and development of next-generation immunomodulatory small molecules inducing transcriptional reprogramming of macrophage function to combat cancer and other diseases, announced today that it has appointed Venkat Reddy PhD as Chief Scientific Officer (CSO) and David Moffat PhD, MPL co-founder and former director of chemistry, as Chief Technology Officer (CTO).

Commenting on the appointments, Dr Søren Bregenholt, MPL Chief Executive Officer said: “On behalf of the executive team I am pleased to welcome Venkat as CSO and David in his new role as CTO as the Company progresses to its next stage of development. Venkat’s deep understanding of pharmaceutical R&D, extensive experience in drug discovery, translational research and early development combined with David’s profound knowledge of our foundation Esterase Sensitive MotifTM (ESMTM) technology, which he co-invented, and drug discovery, will continue to be invaluable as we advance towards clinical trials this year, diversify the technology platform and build out the pipeline to address multiple indications.”

Dr. Venkat Reddy, CSO of Macrophage Pharma, commented: “I am excited to join Macrophage Pharma as CSO and look forward to advancing and expanding the Company’s unique technology platform, exemplified by a drug candidate on track to enter clinical trials. This novel platform allows us to manipulate macrophage and other immune cell functions with the potential to impact areas of unmet need. The differentiation of MPL’s foundation technology from contemporary immune-oncology approaches offers an effective route to functional manipulation of macrophages in the tumour microenvironment by inhibiting local immunosuppression and leading to more effective anti-tumour immune responses. I look forward to working with the management and board to unlock the full therapeutic potential of the ESMTM platform to deliver first-in-class therapeutics to patients with significant pathologies.”

Dr. David Moffat, CTO, MPL, added: “I am very pleased to be taking the helm as CTO at MPL as we progress our lead asset into clinical trials and diversify and advance our preclinical pipeline to embrace additional drug targets and lead chemistries. The differentiated approach of our technology has the reach to address multiple indications where the immune system is dysregulated by aberrant macrophage activity, for potentially wide-ranging clinical benefit. As co-originator of the ESMTM technology I am proud of MPL’s achievements to date and look forward to working with our enhanced team in support of the further growth and development of Macrophage Pharma.”

Venkat brings over 15 years of experience in the biopharmaceutical industry most recently with Glenmark Pharmaceuticals where he was a senior vice president and global head of translational sciences leading the translational programmes of the Company’s innovative preclinical and clinical portfolio. He co-founded APC Therapeutics Inc., a small molecule immuno-oncology startup, the lead programme of which was licensed to Glenmark. Previously, Dr Reddy acted as a senior director of strategic partnerships at Pfizer’s Center for Therapeutic Innovation. Prior to that he held roles with Sanofi, as head of bio-innovation and as global head of oncology target discovery where he was involved in target identification and validation (TIDVAL) function and progression of multiple programmes from preclinical to clinical trials. Before joining Sanofi, Dr Reddy was a group leader in oncology drug discovery at the Novartis Institute for Functional Genomics, San Diego. He received his PhD in human biology at Ludwig Maximilians Universität, Munich and completed a post-doctoral fellowship in oncology and immunology at Scripps Research Institute, La Jolla.

Dr Moffat co-founded MPL in November 2014 and is co-inventor in the discovery and development of the ESMTM technology platform. Previously he has been director of chemistry at Chroma Therapeutics from 2004 to 2012, during which three molecules from his chemistry team were progressed to the clinic including the macrophage-targeted histone deacetylase inhibitors CHR-2845 and CHR-5154. He was also head of chemistry at Celltech from 2001 to 2004, prior to its acquisition by UCB, having begun his industrial career there in 1989. Dr Moffat has extensive experience in oncology and inflammation preclinical research and has led groups which have identified numerous clinical development candidates in these therapeutic areas. He holds BSc and PhD degrees from the University of Glasgow and is author and inventor on more than 70 patents and publications.

Macrophage Pharma at JP Morgan Healthcare Conference, San Francisco

Søren Bregenholt and Venkat Reddy will be at the 38th Annual J.P. Morgan Healthcare Conference on 13-16 January 2020 in San Francisco, California.

Søren Bregenholt will also be presenting at Biotech Showcase 2020 (13-15 January 2020) on Monday 13th January 2020 at 3pm in Franciscan B (Ballroom Level).

Please get in touch, details below, if you would like to set up a meeting.


About Macrophage Pharma

Based on its proprietary Esterase Motif Technology™ (ESM™) platform, Macrophage Pharma is developing a novel and unique class of small molecule therapeutics which modulate immune responses though transcriptional reprogramming of monocytes and macrophages to combat disease. The Company’s novel ESM™ technology platform is designed to deliver small molecule drugs to macrophages in a highly selective manner. The Company is developing multiple programs inhibiting key pathways in macrophages in disease including the lead, a macrophage targeted p38 MAPK inhibitor programme.

The Company was founded by the CRT Pioneer Fund (CPF) and concluded a Series A financing in 2017 with CPF, Aglaia Oncology Funds, Novo Holdings A/S and M Ventures. Please visit the company website for further information:


Macrophage Pharma Limited

Dr Søren Bregenholt, Chief Executive Officer,


Tel: +45 27284533

Optimum Strategic Communications

Hollie Vile, Mary Clark, Supriya Mathur


Tel: +44 (0) 203 714 1789